The Global Apheresis Blog
Exploring the science of therapeutic apheresis, clinical breakthroughs, and what they mean for your health.
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March 2026
The AMBAR Trial: What It Means for Alzheimer's Patients and Families
The AMBAR trial showed therapeutic plasma exchange slowed Alzheimer's progression by 52–71%. Here's what the data means for patients and families.
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April 2026
Plasmapheresis vs. EBOO: What Patients Should Know
EBOO is marketed as a blood-cleansing alternative to plasmapheresis. But its filter doesn't separate plasma, its 'detox' evidence is likely fibrin clots, and its mechanism causes oxidative stress, the opposite of what TPE achieves.
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March 2026
What Joe Rogan Got Right About Plasmapheresis
Joe Rogan posted about plasmapheresis to millions of followers. Here's what the science actually says, from a practice that's performed over 15,000 procedures.
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March 2026
CIRS Treatment with Plasmapheresis: A New Approach to Chronic Inflammatory Response Syndrome
Jordan Peterson's CIRS diagnosis put a name on a condition millions live with undiagnosed. At Global Apheresis, we're treating CIRS with plasmapheresis — addressing what oral protocols cannot.
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March 2026
Therapeutic Plasma Exchange at the Global Longevity Federation 2026 in Rome
Dr. Dobri Kiprov presented on therapeutic plasma exchange for healthspan extension at the Global Longevity Federation 2026 in Rome, Italy.
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March 2026
What Is Inuspheresis — And How Does It Compare to TPE?
Inuspheresis is generating significant interest among patients researching apheresis therapy. Here's what it is, where it's available, and how it compares to TPE.
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March 2026
What to Expect During Your First TPE Session
From preparation to recovery, a step-by-step guide to help you feel prepared and comfortable before your first therapeutic plasma exchange session.
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March 2026
How Therapeutic Plasma Exchange Reduces Biological Age
A 2022 GeroScience study and a 2025 Buck Institute multi-omics analysis confirm that therapeutic plasma exchange measurably reduces biological age. Here's what the science shows and what it means for patients.
Read Article →Peer-Reviewed Publications
Key publications from over 100 peer-reviewed works spanning four decades of advancing therapeutic apheresis.
Fuentealba M, Kiprov D, Schneider K, Mu WC, Kumaar PA, Kasler H, Burton JB, Watson M, Halaweh H, King CD, Yuksel ZS, Roska-Pamaong C, Schilling B, Verdin E, Furman D. “Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange.” Aging Cell. 2025 Aug;24(8):e70103.
View Publication →Kim D, Kiprov DD, Luellen C, et al.. “Old Plasma Dilution Reduces Human Biological Age: A Clinical Study.” GeroScience. 44, 2701-2720, 2022.
View Publication →Mehdipour M, Etienne J, Liu C, Mehdipour T, Kato C, Conboy M, Conboy I, Kiprov DD. “Attenuation of Age-Elevated Blood Factors by Repositioning Plasmapheresis: A Novel Perspective and Approach.” Transfus Apher Sci. 2021 Jun;60(3):103162.
View Publication →Kiprov D. “Therapeutic Plasma Exchange (TPE) and Blood Products — Implications for Longevity and Disease.” Transfus Apher Sci. 2021 Jun;60(3):103163.
View Publication →Mehdipour M, Skinner C, Wong N, Lieb M, Liu C, Etienne J, Kato C, Kiprov D, Conboy MJ, Conboy IM. “Rejuvenation of Three Germ Layers Tissues by Exchanging Old Blood Plasma with Saline-Albumin.” Aging (Albany NY). 12, 8790-8819, 2020.
View Publication →Kiprov D. “Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence — A Hypothesis.” J Clin Apheresis. 28:387-389, 2013.
View Publication →Boada M, Kiprov D, Anaya F, Lopez OL, Nunez L, Olazaran J, Lima J, Grifols C, Barcelo M, Rohe R, Prieto-Fernandez C, Szczepiorkowski ZM, Paez A. “Feasibility, Safety, and Tolerability of Two Modalities of Plasma Exchange with Albumin Replacement to Treat Elderly Patients with Alzheimer’s Disease in the AMBAR Study.” J Clin Apher. 2023 Feb;38(1):45-54.
View Publication →Boada M, Lopez OL, Olazaran J, Nunez L, Pfeffer M, Puente O, Pinol-Ripoll G, Gamez JE, Anaya F, Kiprov D, Alegret M, Molina-Porcel L, Bozzo J, Szczepiorkowski ZM, Hendrix S, Paez A. “Neuropsychological, Neuropsychiatric, and Quality-of-Life Assessments in Alzheimer’s Disease Patients Treated with Plasma Exchange with Albumin Replacement from the Randomized AMBAR Study.” Alzheimer’s and Dementia. 2021.
View Publication →Boada M, Lopez O, Nunez L, Olazaran J, Pfeffer M, Paricio M, Lorites J, Pinol G, Gamez J, Anaya F, Ortiz P, Kiprov D, Grifols C, Torres M, Costa M, Bozzo J, Szczepiorkowski Z, Hendrix S, Paez A. “A Randomized Controlled Clinical Trial of Plasma Exchange with Albumin Replacement for Alzheimer’s Disease: Primary Results of the AMBAR Study.” Alzheimer’s and Dementia. June 4, 2020.
View Publication →Kiprov DD, Herskowitz A, Kim D, Lieb M, Liu C, Watanabe E, Hoffman JC, Rohe R, Conboy MJ, Conboy IM. “Case Report: Therapeutic and Immunomodulatory Effects of Plasmapheresis in Long-Haul COVID.” F1000Res. 2021 Nov 24;10:1189.
View Publication →Kiprov D, Conboy MJ, Conboy IM. “Immunomodulation for the Management of Corona Virus Disease (COVID-19).” Transfus. Apher. Sci.. 59, 102856, 2020.
View Publication →Kiprov D, Hanson C, Sheppard H. “Alloimmunization to Prevent AIDS?.” Science. vol. 263, p. 737, February 1994.
Mitterman A, Bertram D, Snyder H, Messerschmidt G, Diavarella D, Ainsworth S, Kiprov D, Arlin Z. “Treatment of Patients with HIV Thrombocytopenia and Hemolytic Uremic Syndrome with Protein A (Prosorba Column) Immunoadsorption.” Seminars in Hematology. 1989, 26:15-18.
Kiprov D, Pfaeffl W, Parry G, Lang W, Miller R. “Antibody-Mediated Peripheral Neuropathies Associated with ARC and AIDS: Successful Treatment with Plasmapheresis.” J Clin Aphere. 4:3-7, 1988.
Kiprov D, Lippert R, et al.. “Antilymphocyte Antibodies and Seronegative Hemophiliacs.” New England J. of Med.. 313:1514-1515, 1985.
Kiprov D, Simpson DM, et al.. “Use of Staphylococcal Protein A Immunoadsorption Column in Treating Immune-Mediated Disease.” J Biol Response Modifiers. 3:330-346, 1985.
Lipkin I, Parry G, Kiprov D, et al.. “Inflammatory Neuropathy in Homosexual Men with Lymphadenopathy.” Neurology. 35:1479-1483, 1985.
Abrams D, Kiprov D, Volberding P. “Isolated Thrombocytopenia in Homosexual Men — Longitudinal Follow-up.” AIDS-Associated Syndromes: Advances in Experimental Medicine and Biology. 187:117-122, 1985.
Kiprov D, Miller R. “Polymyositis Associated with Benign Monoclonal Gammopathy.” Lancet. II: 1183-1186, 1984.
Kiprov D, Morand P. “The Effect of Plasmapheresis and Immunosuppressive Drug Therapy on T-Cell Subsets as Defined by Monoclonal Antibodies.” J Clin Aphere. 1-57, 1983.
Kiprov D, Colvin R, McCluskey R. “Focal and Segmental Glomerulosclerosis and Proteinuria Associated with Unilateral Renal Agenesis.” Lab Invest. 46:275, 1982.
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